Aureus Pharma's Knowledge Management System

The drug discovery process is notoriously complex and time-consuming. Fortunately, advancements in technology are paving the way for a more efficient future. Aureus Pharma's Knowledge Management System (KMS) stands out as a unique solution designed to accelerate this critical process.

Turning Data into Discovery

Aureus Pharma's KMS is the only life sciences information solution that integrates structured knowledge databases with powerful search and analysis capabilities. This translates to a system that doesn't just store data, but actively transforms it into actionable insights for researchers.

Structured Knowledge Databases:  At the core of the KMS lie comprehensive databases containing meticulously organized biological and chemical information. These databases focus on key areas of drug discovery, including:

Therapeutic target families: GPCRs (G protein-coupled receptors), Ion Channels, and Kinases. These are proteins that play crucial roles in various biological processes and serve as potential targets for new drugs. The human beta-2 adrenergic receptor in complex with the partial inverse agonist carazolol[1]

Safety-related themes: ADME/Drug-Drug Interactions (Absorption, Distribution, Metabolism, and Excretion) and the hERG channel, which is critical for heart function and must be considered for drug safety.

Powerful Search and Analysis:  The KMS goes beyond data storage by offering researchers advanced search functionalities and analytical tools. This allows for efficient exploration of the knowledge base, enabling researchers to identify relationships between protein targets, biological functions, and potential drug candidates (ligands).

Benefits for Researchers

By providing a centralized platform with structured data and powerful analysis tools, Aureus Pharma's KMS empowers researchers in several ways:

Reduced Research Time: The ability to efficiently search and analyze vast amounts of data streamlines the drug discovery process, potentially leading to faster identification of promising drug candidates.

Improved Decision-Making: The KMS facilitates data-driven decision making by providing researchers with a comprehensive view of potential targets, their biological functions, and the available ligand information.

Enhanced Collaboration: The web-based interface of the KMS fosters collaboration among researchers by providing a shared platform for accessing and analyzing data.

Success Stories

The effectiveness of Aureus Pharma's KMS is evident in its adoption by leading pharmaceutical companies. Here are a few examples:

Neuromed Pharmaceuticals: This company, focused on chronic pain drugs, has licensed the AurSCOPE Ion Channel Knowledgebase, leveraging the power of the KMS for their research efforts. Ion channels; (A) An ion channel is open, allowing the flow of Ca 2+ ions, (B) A closed ion channel limiting the flow of ions, (C) A truncated (diseased) ion channel not trafficked to the membrane due to dismantled subunits.

Bristol-Myers Squibb: This pharmaceutical giant has not only renewed its agreement for the AurSCOPE GPCR knowledgebase but has also expanded its partnership by licensing AurSCOPE Kinase and AurSCOPE Ion Channel.

The Future of Drug Discovery:

Aureus Pharma's KMS represents a significant leap forward in drug discovery research. By providing a comprehensive knowledge management platform, the company is empowering researchers to accelerate the development of new and life-saving treatments.

in News
Une Plongée dans les Composants du Kit Urinaire LC-MS/MS
Déverrouiller les Mystères des Amines Biogènes