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AurSCOPE® ADME/DDI Database

AurSCOPE® ADME provides the latest and most comprehensive data for structurally diverse compounds associated with known ADME properties, including human oral bioavailability, enzymes metabolism, inhibition and induction, transport, plasma protein binding and bloodbrain barrier.

The database includes data from peer-reviewed journal articles, patents, Clinical Pharmacology Biopharmaceutics Review(s) section of NDA submissions, product labels for recently approved drugs (from 2000 to date) and European Public Assessment Report (EPARs).

Designed for utilization by all researchers in the drug discovery field, AurSCOPE® ADME is updated and upgraded to customers quarterly .

Main Features

  • Pharmacokinetic on healthy subjects and patients (renal, liver impairment, cancer and more)
  • Compartmental and non compartmental PK results
  • Phenotyping (Extensive versus poor Metabolizers) and genotyping data
  • DDIs retrieve from peer-reviewed journal articles, Clinical Pharmacology Biopharmaceutics Review(s) section of NDA submissions and European Public Assessment Reports (EPARs)
  • Phase I, Phase II and Phase III enzymes kinetic data (Km, Vmax, IC50, Ki, KI, EC50, t1/2...)
  • Kinetic data on HLM, hepatocytes, recombinant systems (baculovirus, lymphoblastoid, e. coli, yeast)
  • Export to Excel, SD or text files

  • Download the PDF

    AurSCOPE ADME/DDI Uses - See Example

  • Identify potential drug-drug interactions
  • Address early ADME issues into lead optimization programs
  • Preclinical drug discovery as well as clinical drug development
  • Facilitate enlightened strategic decision-making regarding project management
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