AurSCOPE® ADME/DDI Database
AurSCOPE® ADME provides the latest and most comprehensive data for structurally diverse compounds associated with known ADME properties, including human oral bioavailability, enzymes metabolism, inhibition and induction, transport, plasma protein binding and bloodbrain barrier.
The database includes data from peer-reviewed journal articles, patents, Clinical Pharmacology Biopharmaceutics Review(s) section of NDA submissions, product labels for recently approved drugs (from 2000 to date) and European Public Assessment Report (EPARs).
Designed for utilization by all researchers in the drug discovery field, AurSCOPE® ADME is updated and upgraded to customers quarterly .
Main Features
Pharmacokinetic on healthy subjects and patients (renal, liver impairment, cancer and more)
Compartmental and non compartmental PK results
Phenotyping (Extensive versus poor Metabolizers) and genotyping data
DDIs retrieve from peer-reviewed journal articles, Clinical Pharmacology Biopharmaceutics Review(s) section of NDA submissions and European Public Assessment Reports (EPARs)
Phase I, Phase II and Phase III enzymes kinetic data (Km, Vmax, IC50, Ki, KI, EC50, t1/2...)
Kinetic data on HLM, hepatocytes, recombinant systems (baculovirus, lymphoblastoid, e. coli, yeast)
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