Paris, France, April 13th, 2010 -- Taking benefit of the vast amount of literature data already available and structured in our knowledge management platform , in silico profiling of several marketed drugs was performed in order to find new potential targets and therefore identify some opportunities of new therapeutic indications.
Our scientific team utilized an integrated tool, AurPROFILER, able to rapidly search across all target knowledge databases to identify drug profiles. We performed chemical and 2D pharmacophoric similarity searches for several drugs and created targets/similar compounds profiles. Results are displayed as interactive heat maps with a color code representing activity values allowing us to rapidly compare profiles with the requested drug and to spot new potential targets. Examples of drug reprofiling were presented and discussed in this paper.
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