.:: Aureus Pharma ::.

AurPROFILER™ rapidly conducts thorough searches across all individual AurSCOPE Target Knowledge Databases or AurSCOPE Global Pharmacology Space (AurSCOPE GPS) to rapidly identify target, cell or drug/compound profiles. Results are displayed as interactive “heat maps” for easy visualization and navigation of the pharmacological space - the target or cell. Using AurPROFILER™ provides new insights into target selectivity, off target effects, cell cytotoxicity and other issues crucial to the discovery process.

Key features include:

• Creation of target/compound or cell line/compound profile based on knowledge derived from AurSCOPE® Knowledge Databases

• Interactive profile Heat Map visualizations

• Activity values in Heat Map are expressed using a unified parameter (-log of affinity/activity value) and link to detailed experimental literature data

• Compound searches based on exact structure, substructures or similarity searches

• Filtering of data within the Heat Map based on chemistry and biology-based parameters:

activity
species
bioassay Protocols
publication type : patents or journal articles
compound physicochemistry Properties (MW, Log P, & others)
hierarchy of chemistry-based on Bemis & Murko framework
global target hierarchy based on standard classifications

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